Open Access

The Eurozone faces growing economic and environmental challenges, with supply chain disruptions causing losses of over EUR 112.7 billion in 2021. Climate change, geopolitical risks, regulatory shifts, and infrastructure weaknesses strain intermodal freight transport, highlighting the need for digital solutions to enhance resilience and efficiency. This paper examines key challenges in intermodal freight transport, including disruption triggers, network vulnerabilities, and inefficiencies in disruption management. Extreme weather, and capacity shortages impact both performance and sustainability. Using the Total Quality Framework (TQF), the research includes interviews with 23 stakeholders from 10 countries, focus workshops, and surveys. The analysis reveals shortcomings in real-time data integration, interoperability, and disruption response. Regulatory fragmentation and low digital maturity hinder resilience strategies. Addressing these gaps requires harmonized data frameworks, improved interoperability, and the use of collaborative digital platforms. The Horizon Europe project ReMuNet leverages intelligent algorithms and digital platforms to enhance multimodal networks, optimize route planning, and improve disruption response, contributing to the vision of the Physical Internet.