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The complexity and volatility of companies’ environment increase the relevance of disruption preparation. Resilience enables companies to deal with disruptions, reduce their impact and ensure competitiveness. Especially in the context of procurement, disruptions can cause major challenges while resilience contributes to ensuring material availability. Even though past disruptions have posed various challenges and companies have recognized the need to increase resilience, resilience is often not designed systematically. One major challenge is the number of potential measures to increase resilience. The systematic design of resilience thus requires a detailed understanding of domain-specific measures. This also includes an understanding of the contribution of these measures to different resilience components and their interdependencies. This paper proposes a systematic approach for configuring resilience in procurement which enables the evaluation and selection of resilience measures. Based on a resilience framework, a resilience configurator is developed. The basis of the configurator are resilience potentials that have been characterized and clustered. Overarching approaches to design resilience and indicators to evaluate resilience are presented. Moreover, a procedure is proposed to ensure practical applicability. To evaluate the results two case studies are conducted. The results enable companies to systematically design their resilience in procurement.